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From Pipettes to Infusion Pumps: Volume Accuracy in Regulated Industries and Its Critical Impact
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Special Reports
As the monoclonal-antibody (mAb) market continues to grow, it is becoming increasingly important for pharmaceutical and biotech companies to accelerate process development and establish a scalable manufacturing process capable of achieving high titers and consistent product quality. Central to this is a cell culture media and feed system that can provide the required nutrients for optimal cell growth, viability, and function, as well as facilitate a seamless transition from development to clinical and commercial manufacturing. However, choosing an appropriate system can be a complex and time-consuming process, often requiring the evaluation of multiple medium and feed options. Platform systems, consisting of a medium and complementary feed developed for a specific cell line and application, have emerged as a valuable option for developers to help simplify selection and increase scale-up efficiency. To meet the need for high-performance platform mAb manufacturing solutions, Thermo Fisher Scientific has dev...
Precision in volume delivery is critically important for both the biopharmaceutical and medical device industries. This special report discusses how accurate volume measurement affects patient safety, product quality, and regulatory compliance. Sartorius emphasizes the roles that infusion pumps, laboratory pipettes, and quality control (QC) measures play in ensuring reliable and reproducible results. Register or Login and hit Download Now to get the full Special Report.
Ask the Expert Webcasts
This webcast features: Marissa Dickson, Scientist II, & Brian Hadley, Principal Scientist, Lonza Biologics. One strategy for lowering cost of goods (CoGs) of biotherapeutics manufacturing is by dramatically increasing the productivity of the bioreactor process. Lonza R&D has developed an intensified process that couples a perfused N-1 inoculum bioreactor, enabled by alternating tangential flow filtration, to a fully-automated high inoculation density (HID) production stage reactor. This reactor demonstrates substantial increases in bioreactor productivity compared to a low inoculation density control fed-batch process. Significant titer increases between LID and HID processes have been demonstrated with a panel of six CHOK1SV GS-KO® cell lines expressing three different monoclonal antibodies. In addition, increases in product concentration while maintaining comparable product quality were observed in process intensification for two cell lines expressing unique novel molecular formats: a monospecific ...
This webcast features: Gregory Verni, Vice President, Fluid Management, Scott Bendon, Senior Director of Engineering, Flow Control Technologies, Fluid Management, & Derek Masser, Director of Business and Market Development, Fluid Management, Repligen. Navigating the complexities of single-use bioprocessing involves managing numerous components, addressing inefficiencies, mitigating supply chain risks, and budget constraints. Your single-use partner should drive the innovation needed to overcome these challenges and transform ideas from the back of the napkin to your cleanroom floor, so you can focus on delivering life-changing therapeutics quickly and efficiently. This webinar analyzed three case studies, each highlighting different approaches to single-use collaboration. These real-world examples illustrate key considerations when working with single-use suppliers, helping you streamline your processes and prioritize what matters most. Key Takeaways: Register or Login and hit Watch on Demand to vie...
