![Gilead: ‘Cell therapy is at the very early stages of its penetration’ Gilead: ‘Cell therapy is at the very early stages of its penetration’](https://eu-images.contentstack.com/v3/assets/blt0a48a1f3edca9eb0/blt92d9f2b58ec23cb4/658ae62addc46b040761b8fd/cancer.jpg?width=1280&auto=webp&quality=95&format=jpg&disable=upscale)
Gilead Sciences says the advent of cell therapies into second line treatments and increased competition in the space will help boost the “under-penetrated” market.
Having entered the cell and gene therapy space in August 2017 through the $11.9 billion acquisition of Kite Pharma, Gilead Sciences has cemented itself as a pioneer in the sector through the commercialization cell therapies: Yescarta (axicabtagene ciloleucel), approved in the US in October 2017, and Tecartus (brexucabtagene autoleucel) approved in July 2020.
According to Gilead’s CEO Dan O’Day, sales of the two chimeric antigen receptor (CAR) T-cell therapies attributed around $401 million to the firm’s topline for the first six months of the year, but their potential is much higher.
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Yescarta, for example, was approved as a third-line treatment for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), meaning it would only be administered after no response was seen after at least two other kinds of treatments.
Speaking at the Morgan Stanley 19th Annual Global Healthcare Conference last week, O’Day referenced the ongoing ZUMA‐7 trial, which is assessing Yescarta’s potential as a second-line therapy. Describing it as “a fundamental turning point” for cell therapy.
“The most substantial readouts for frankly the whole field of cell therapy, let alone Kite, was the second line ZUMA‐7 trial, and of course we look forward to showing you more details on that at ASH later this year,” he told delegates.