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Simplify and Intensify Cell Culture: XCell™ ATF Systems for Cell Culture Process Intensification Now Available in Single-Use Format

Rachel Goodrich

August 11, 2016

2 Min Read

14-7-Repligen-logo-300x56.jpgA finalist for the 2012 BPI Technology of the Decade Award, XCell™ ATF systems consistently yield high cell retention, concentration, and viability, enabling efficient and productive perfusion and N – 1 perfusion as well as cell banking and seed-train cell culture operations.


Figure 1: Scalable from laboratory to production: XCell™ ATF systems include the device and controller. XCell™ ATF single-use device (left) are available in two sizes. XCell™ ATF stainless steel device (right) are available in five sizes.

XCell™ ATF devices are now available in single-use format, in addition to stainless steel. The new single-use devices deliver 100% cell retention and laboratory-to-production scalability like their stainless steel counterparts but without the need for autoclave sterilization and lengthy setup times.


Figure 2: Alternating tangential flow (ATF) technology: XCell™ systems use ATF technology created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor.

Features and benefits of XCell™ ATF Systems include

  • Continuous, provides clarified harvest ready for capture chromatography

  • Efficient, delivers 100% cell retention to increase productivity

  • Intensified, generates high cell concentration and viability

  • Flexible, connects to any bioreactor and can be used in a range of applications

  • Gentle, reduces cell stress, increases cell viability, and productivity

  • Easy to use, single-use reduces setup time and documentation

  • Scalable, adapts from development scale to production scale

  • Self cleaning, pump action reduces hollow-fiber filter fouling and increases throughput


Figure 3: Continuous processing; high cell density with high viability perfusion at 100E6 cells/mL was achieved using an XCell™ ATF 2 system.

Learn more at www.repligen.com.

Rachel Goodrich is senior director of marketing at Repligen, 41 Seyon Street, Building 1, Suite 100, Waltham, MA 02453; [email protected]; www.repligen.com.

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