Scalable, Real-Time Bioprocess Monitoring Solution: Kaiser Raman Technology and Sartorius BioPAT Spectro Yield Value from Early Process Development to Single-Use Manufacturing

Maryann Cuellar

August 12, 2021

1 Min Read

19-7-8-EndressHauser-LOGO-300x100.jpg19-7-8-EndressHauser-P2-300x225.jpgRaman spectroscopy is used in biomanufacturing as a process analytical technology (PAT) tool for making rapid, nondestructive, in-process measurements. However, Raman data collection at early stages of bioprocess development has been a challenge because of the lack of interface to bioreactors <250 mL. Realizing the industry was struggling to capitalize on the full potential of Raman spectroscopy, Kaiser Optical Systems, Inc. (Kaiser), an Endress+Hauser company, collaborated with Sartorius to bring Raman to Ambr 15 microbioreactors (10–15 mL) and Ambr 250 minibioreactors (100–250 mL). Sartorius’s new BioPAT Spectro platform enables Kaiser Raman–based quality by design (QbD) early in process development and scales up to Biostat STR single-use bioreactors.

The following Q&A explains how Kaiser Raman technology and the BioPAT Spectro platform by Sartorius work together to provide biopharmaceutical manufacturers with scalable, real-time bioprocess monitoring.

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