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Innovation of Novel Purification Strategies – A Case Study of a Clusterin Scavenger Resin

BPI Contributor

May 23, 2023

20 Min View
Innovation of Novel Purification Strategies – A Case Study of a Clusterin Scavenger Resin

Date: May 23, 2023

Duration: 20 Min

Affinity chromatography resins employ target-specific ligands attached to a stationary phase and are commonly used to capture therapeutic entities in biologics manufacturing, reducing the number of required purification steps and increasing overall yield.

A less common but powerful use of affinity purification is the removal of problematic impurities, such as host cell proteins. Both techniques require high-specificity affinity ligands with sufficient capacity, stability, and suitability for clinical manufacturing.

In this webinar, we present the development of a novel scavenging resin for clusterin, a persistent CHO host cell protein commonly observed in monoclonal antibody manufacturing processes.

Key Takeaways:

  • Understand platform process for the generation of highly specific VHH antibody-based ligands and affinity resin development for bioproduction.

  • Analyze performance data and sample chromatography condition for POROSTM CaptureSelectTM ClusterinClear affinity resin.

  • Review custom resin development process and timeline.

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