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Enhancing Virus Clearance Process Capability Using a Biodegradable Detergent

BPI Contributor

February 9, 2024

1 Min Read

Does your high concentration mAb need a new approach to viral clearance? Low pH treatment can lead to instability, and Triton X-100 was placed on the Substances of Very High Concerns (SVHC) list by the European Chemicals Agency under REACH regulations. To overcome these challenges, Avantor R&D scientists developed a novel, detergent-based viral inactivation solution that is both sustainable and highly efficient.

Comprehensive study data illustrate key performance parameters of readily biodegradable J.T.Baker® Viral Inactivation Solution, including:

  • High virus killing kinetics (> 6.5 LRV) independent of operational temperatures

  • Compatibility across a range of molecules and with subsequent process steps

  • Preserves protein integrity for product stability

  • No impact on dynamic binding capacity or yield

  • Successfully clears from the final product

As a filtered and ready-to-use detergent, this solution is not only effective, but it eliminates the requirement and risk of preparing sterile viral inactivation buffers in-house. Its high concentration requires less detergent volume to reduce costs. Low foam height and viscosity minimizes process challenges, enabling easier fluid handling and fewer engineering concerns.

Read the study results that highlight key quality advantages of this new viral inactivation solution — particularly for bispecific or multispecific antibodies — that minimize process challenges and risk to achieve cost, time and labor savings.

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