Products, Services, and Literature February 2008

BPI Contributor

February 1, 2008

8 Min Read

Filtration Pumping


Product: 620RE filtration pump

Applications: Dead-end filtration and tangential flow filtration (TFF)

Features: Gentler on the product in terms of shear stress when producing higher yields; provides unrivaled performance with a control ratio of 2650:1; requires minimal maintenance with no valves or seals to clog, resulting in reduced downtime; offers exclusive innovative PIN-secure protection feature that provides two levels of PIN protection; speed range can be capped to prevent accidental damage to delicate filters; keypad functionality can be disabled to avoid inadvertent changes to pump settings in sensitive fermenation processes; pumps contain fluid in the tubing at all times, never allowing the fluid to come into contact with the pump mechanism and ensuring gentle, low shear handling

Contact Watson-Marlow Bredel

Pressure Sensors


Product: Single-use pressure sensors (patent pending)

Application: Single-use processing systems

Features: Caustic-resistant polysulphone pressure sensors are compatible with single-use bioprocess systems made of bags, filters, tubing, and connectors; qualified for exposure to 1N NaOH for over three hours at 50 °C; feature an unobstructed flow path without dead-legs that minimizes pressure drops associated with some pressure measurement devices; available for tubing from inner diamater size 0.375 in. to 1 in., capable of handling flow rates up to 50 L/min; manufactured in an FDA-registered, ISO 13485 certified facility

Contact PendoTECH

Process Equipment Welding


Product: M200 power supply for welding systems

Applications: Fluid system and processing equipment fabrication and repair

Features: Offers ease-of-use, portability, and 200-amp capability; high-resolution 12.1 in. (307 mm) color industrial touch-screen provides users with an intuitive pathway to enter weld programs; includes three forms to for entry, with automatic weld schedule programming; automatic shield-gas control (patent pending), simplifies set-up of shielding gas, requiring no use of a separate flowmeter; multiple language capability is built in, requiring no separate programming or special ordering; includes four USB ports, ethernet ports, USB device (output) port, VGA output, and serial port and is compatible with all available Swagelok weld heads

Contact Swagelok

Laboratory Equipment

Literature: 2008 New Brunswick Scientific laboratory equipment catalog

Applications: Product and process development

Features: Shakers, fermentors, bioreactors, CO2 incubators, ultralow-temperature freezers, automated cell counters, and air sampling systems are offered along with hundreds of other laboratory products and accessories; includes several new fermentor and biorector models for pilot and production-scale operations as well as OPC-compliant bioprocessing softwar, and an assortment of products for culture growth, detection, and storage

Contact New Brunswick Scientific


Product: TOYOPEARL GigaCap Q-650M anion-exchange resin

Applications: High-throughput purification of proteins and nucleic acids

Features: Developed to meet needs in high-throughput purification of monoclonal antibodies and other proteins by packed-bed chromatography at process scale; improved resins are rigid with high binding capacities capable of withstanding high flow rates and harsh purification procedures; based on well-proven methacrylic polymer backbone of TOYOPEARL and TSK-GEL media; uses latest surface modifcation technology to increase the content of functional groups at the particle surface to reach binding capacities of over 170 mg BSA and over 100 mg IgG per milliliter resin

Contact Tosoh Bioscience

Nucleic Acid Isolation

Product: Dynabeads MyOne SILANE and viral NA and genomic DNA kits

Applications: High-sensitivity and high-capacity assays

Features: Beads and kits support isolation of viral RNA and DNA or pure genomic DNA of high integrity; provide highly reproducible and predictable isolation of total nucleic acids from biological samples; validatable magnetic beads are uniform in size-range distribution, surface area, and binding capacity

Contact Invitrogen

Accident Prevention

Literature: A “Six Step” Process to Investigate and Prevent Laboratory Accidents

Applications: Laboratory work environments

Features: Free white paper details six key components of an accident investigation and mitigation program necessary to provide improvements in an overall safety program and prevent accidents

Contact EH&E

MAb Enhancement

Technology: DXL technology available for licensing

Applications: Improving monoclonal antibodies

Features: Dynamic cross-linking increases target antigen binding, enhances antibody effector function, and installs new properties into antibodies such as the ability to trigger apoptosis in cancer therapeutics; integrates self-binding peptides onto MAb molecules, potentiating target binding; modified antibodies cluster at the target receptor site for greater molecular mass at the point of association; significantly extends dissociation rates (measured by surface plasmon resonance)

Contact InNexus Biotechnology, Inc.,

Filling System


Product: FPC50 semiautomated filling and plugging system

Applications: Filling for clinical trials

Features: Flexibility and fast-changeover in small-batch filling for clinical trials; compact, space-saving system has been developed to handle filling requirements for clinical trials, offering easy transfer into a full production scale-up operation; simple changeover of the single-use fluid path, includes pharmaceutical
grade silicone tubing and plastic filling needle, simplifying the filling and validation process for multiple batch and/or product fills; fast, easy-change tubing diameter accommodates a range of vial sizes and neck finishes; automated precision turntable infeed, in-line filling station, and a rubber plug applicator fills and caps vials at a rate of 25 vpm

Contact Flexicon



Product: No. 970 500 °F (∼260 °C) electrically heated, class 100 cleanroom oven

Applications: Sterilization, depyrogenation, curing, and drying

Features: Unit measures 33-in. wide × 42-in. deep × 66-in. tall; heated by 30-kW Incoloy-sheathed tubular elements; a 2,400 cfm, three-horsepower recirculating blower provides horizontal airflow to the workload; has 4-in. thick insulated walls throughout with aluminized steel exterior, Type 304 2B-finish stainless steel interior with continuously backwelded seams, exterior finished with white epoxy paint, #4 brushed finish stainless steel door and control panel face

Contact Grieve

Single-Use Bioreactor


Literature: CellMaker Lite2 brochure

Applications: Yeast fermentation in a single-use system

Features: 23-page brochure details the growth of Pichia in a unique single-use bioreactor made of low-density polyethylene (LDPE) with an aeration mixing system; includes a technical note written by a third party that implemented the system and analyzed its performance, providing detailed experimental conditions and results data; details the principles of operation for the product and its presterilized bags; provides an educational explanation of the history and use of Pichia pastoris in the production of protein therapeutics

Contact Cellexus Biosystems plc Lite2 Pichia pastoris.pdf

Macromolecular Characterization


Product: Calypso automated protein association and aggregation system

Applications: Characterization of protein-protein interactions in native solution

Features: Uses composition-gradient multiangle light scattering (CG-MALS) so protein samples need not be tagged, immobilized on a surface, or otherwise modified from their natural state; offers sensitive and precise method for measurement of complexes and aggregates through absolute determination of molar mass and nondestructively characterizes both weak and strong interactions; simple or complex stoichochemitries can be analyzed, providing equilibrium dissociation constants from picomolars to millimolars, and self-and cross-viral coefficients and aggregation or association kinetics; consists of hardware and dedicated softwar for automating CG-MALS measurements as well as Zimm plots and dn/dc determinations; sample mixing, dilution, and delivery are automated using computer-controlled syringe pumps while intuitive software controls the experiment, acquires data, and analyzes results

Contact Wyatt Technology

Single-Use Mixing


Product: Mobius MIX100 disposable mixing system

Application: Cell culture, media, and buffer preparation

Features: A configurable 100-L container with integral impeller that enables risk-free mixing with a magnetic motor that eliminates warm-up time; capable of being configured with an array of containers, filters, connectors, and tubing for a validated disposable solution; decreases risk of contamination; reduces downtime for cleaning, validation, and process engineering; increases production capacity at multiproduct facilities

Contact Millipore

Process Monitoring and Control


Product: Control 4000 photometric converter

Applications: Process automation and monitoring

Features: Modular design enables precision process monitoring and control; designed for ultraviolet (UV), visible (VIS), near-infrared (NIR) absorption-based and scattered-light–based sensors; includes a real-time photometric converter, factory zero point for scattered light sensors, integrated data logger for quality control, simple menu-based software, advanced software tools, remote process control functions, and simultaneous operation of up to four inline sensors; provides readings of absorbance, transmittance, and concentration in real time and in any unit of measure including CU, ppm, EBC, FTU, and g/L

Contact optek-Danulat, Inc.


Literature: 2008–2009 Chromatography Columns and Consumables catalog

Applications: Downstream processing

Features: Provides a complete product and technical reference guide that consolidates the range of the company’s chromatography columns and consumables; includes a section containing user-replaceable parts for the most popular chromatography and mass spectrometry systems; offers application and column selection sections, an extensive range of high-performance liquid chromatography products, and individual sections devoted to gas chromatography columns and consumables, solid-phase extraction (SPE) products, and chromatography accessories

Contact Thermo Fisher Scientific

Cell Culture

Product: Cell culture inserts with polycarbonate membranes

Applications: Cell interaction and cultivation studies for tissue engineering, cocultivation, invasion, chemotaxis, and transport

Features: Expands functionality and maneuverability of the NUNC cell culture insert product line; easily removable from multiwell Multidish design, and ideal for sectioning for transmission electron microscopy when using a glass knife; designed with large pore
sizes that make them ideal for invasion and chemotaxis studies; available in four sizes in 24-, 12-, or 6-well Multidish configuration with three pore sizes (0.4, 3, and 8 µm); support a wide range of cell lines in the absence of matrix coating (BHK, MDCK, CACO-2, HeLa, WRC, Hep-G2, HEp-2, L9299, CHO, LLC-PK, and 3T3)

Contact NUNC

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