GSK Q3: Shingrix shines but adjuvant will drive future vaccines

GSK says the adjuvant platform used in Shingrix will be the backbone of its future vaccine strategy

Dan Stanton, Managing editor

November 1, 2019

2 Min Read
GSK Q3: Shingrix shines but adjuvant will drive future vaccines
Image: iStock/AndreyPopov

GSK says the adjuvant platform used in Shingrix will be the “backbone” of its future vaccine strategy. The shingles vaccine pulled in sales of £535 million ($693 million) for the third quarter.

For the quarter, GlaxoSmithKline (GSK) reported group sales of £9.4 billion, up 11% on the previous year. Its vaccines unit grew 15% year-on-year to £2.3 billion with its non-live, recombinant subunit vaccine for the prevention of shingles (herpes zoster), Shingrix, pulling in £535 million – up 76% year-on-year.

Sales of the vaccine benefitted from the opening up of production capacity, following a period of delays and shortages due to high level of demand. However, the Big Biopharma firm has undertaken efforts to alleviate the supply issues and is expanding plants in France and Montana to increase capacity.


Image: iStock/AndreyPopov

GSK management said on a financial call “long may the Shingrix contribution continue,” but noted the firm must look to the product to drive a longer life cycle for its vaccines unit.

Roger Connor, president of Global Vaccines, said he was pleased with the firm’s move into therapeutic vaccination and told investors that “a backbone of that strategy is our adjuvant technology,” which he said is a key part Shingrix’s success.

The adjuvant used in Shingrix is an extract of the Quillaja saponaria tree. According to the FDA label: “The adjuvant suspension component is AS01B which is composed of 3-O-desacyl-4’- monophosphoryl lipid A (MPL) from Salmonella minnesota and QS-21, a saponin purified from plant extract Quillaja saponaria Molina, combined in a liposomal formulation.”

According to Connor, the firm is looking to maximize this to grow its vaccines pipeline, including a COPD vaccine for chronic obstructive pulmonary disease, proof-of-concept data of which is expected next year.

“[In the] U.S. alone where there are 16 million people suffering from COPD,” he said. “We really believe that that vaccine could have a really significant impact to reduce acute exacerbation and disease progression with such a proportion of exacerbation linked to infection that the vaccine will treat.”

This, he continued, is the only vaccine in development for COPD and therefore represents a “huge opportunity” for GSK going forward.

About the Author(s)

Dan Stanton

Managing editor

Journalist covering the international biopharmaceutical manufacturing and processing industries.

Founder and editor of Bioprocess Insider, a daily news offshoot of publication Bioprocess International, with expertise in the pharmaceutical and healthcare sectors, in particular, the following niches: CROs, CDMOs, M&A, IPOs, biotech, bioprocessing methods and equipment, drug delivery, regulatory affairs and business development.

From London, UK originally but currently based in Montpellier, France through a round-a-bout adventure that has seen me live and work in Leeds (UK), London, New Zealand, and China.

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