Wuxi Biologics will make components of COVID-19 vaccines and other biologic products at the facility it bought from Bayer.

Gareth Macdonald

January 4, 2021

2 Min Read
WuXi to make COVID-19 vaccine at shelved Bayer hemophilia drug plant
Image: iStock/JFsPic

WuXi Biologics will make components of COVID-19 vaccines and other biologic products at the facility it bought from Bayer.

The Chinese CDMO acquired the plant in Wuppertal, Germany last month in a deal valued at around €150 million ($185 million).

Bayer had originally planned to use the Wuppertal plant to produce recombinant factor VIII products. However, in November 2018 the firm announced it would not commission the facility.


Image: iStock/JFsPic

A Bayer spokesman told us “the decision was based on a review of our hemophilia business, which highlighted the need to align our Factor VIII (FVIII) production capacity with future market requirements.

“To remain competitive despite the changing market environment, it was imperative that we concentrate the production capacities for rFVIII products in the Supply Center in Berkeley in the US.”

In a press release WuXi said it will “manufacture drug substances for COVID-19 vaccines and other biologics” at the plant. It also plans to invest in additional process equipment.

The facility houses 3 x 1000 L perfusion and 6 x 2000 L fed-batch capacity with independent downstream manufacturing suites.

Lease agreement

The sale includes “long-term sublease agreement.”

The Bayer spokesman told us the sublease covers the provision of plant security, road use, street cleaning, grounds keeping for a period of 10 years.

He explained that, “The use of other services – consumable energy such as clean water, gas, sodium hydroxide – will be recorded and billed according to actual consumption.”

There is a further transitional service agreement (TSA) covering a period of 12 to 14 months. During the TSA phase, Bayer will support WuXi Biologics in commissioning the building/facilities and with the preparations required for future use.

He added, “To this end, Bayer will put together a TSA team with the requisite expertise.”

The plant is not the first WuXi has acquired from Bayer. In January last year the CDMO acquired a plant in neighboring Leverkusen in a deal that also included a long-term lease agreement.

WuXi described the two plants as the “cornerstone” of its European network. It added that the facilities are expected to be ready for drug substance and drug product manufacturing by 2021.

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