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Freeze Cycle Testing of Fluoropolymer Bottles

Eric Isberg

August 27, 2021

1 Min Read

19-7-8-Savillex-P1-300x240.jpgFrozen storage of bulk drug substances (BDS), including bioprocess solutions, vaccines, blood components, and other delicate process fluids is common in the bioprocess industry. Vessels used to store those fluids must be capable of withstanding long-term storage in extremely cold temperatures (e.g., –85 °C or –196 °C), sometimes for very long time periods. They also must also maintain integrity after repeated thawing and subsequent refreeze. The study below was performed to characterize performance of fluoropolymer bottles with standard and two-piece closure systems after multiple freeze–thaw cycles, with a retorque step added after each freeze cycle.

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