Addressing the Risk of Bioburden and the Need for Increased Productivity in Protein A ChromatographySponsored Protein A columns are the weakest link in downstream purification with respect to bioburden risk. Protein A chromatography columns are loaded with cell culture supernatant, creating a beneficial environment for bacterial growth, but the column is subsequently cleaned with the weakest clean in place (CIP) solution.
Sponsored Whether viral vectors are clarified or the bioburden after cell harvest needs to be reduced to recover antibodies, such applications in biopharmaceutical production require large filtration areas. Single-use technologies are indispensable in many such bioprocesses.
Sponsored Many viruses selectively grow in polarized cells, limiting their ability to be produced in suspension culture. The special report includes case studies in three adherent-cell systems and provides an overview of some analytical methods you can use to characterize viral products.