The latest issue of BioProcess International focuses on production, featuring articles on host-cell protein detection in CHO expression systems, raw materials specifications, continued process verification, a response to USP ‹1207›, and an examination of the impact of postgrant proceedings on biosimilars.
Read it Now.
Biopharmaceutical Training Supplement
The success of the biomanufacturing industry relies on its ability to attract and retain a well-trained and motivated workforce that can adapt to new technologies and manufacturing challenges. Yet despite the criticality of workforce education, it never has been a hugely popular topic at conferences and in trade journals. Jointly, BPI and North Carolina State University’s Biomanufacturing Training and Education Center (BTEC) recognized this void, and began a partnership focused on generating an increased level of attention and discussion on professional development in the biopharmaceutical industry. This supplement is one such effort.
Read it Now.
In downstream purification of monoclonal antibodies (MAbs), the single greatest contributor to manufacturing costs is the expensive capture step typically based on protein A affinity chromatography. Almost since its introduction to bioprocessing, efforts have been made to reduce the cost of this step. Several alternative ligands have been promulgated as potential replacements for protein A, but they have proven difficult to adopt and scale up. Supplier companies have pushed for increases in capacity and economics, but those are always accompanied…