Aggregate Removal from Monoclonal Antibody with Nuvia™ HR-S Media
BPI Contributor
October 24, 2013
1 Min Read
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Nuvia HR-S media is a new cation exchanger designed for high resolution of closely related product impurities such as aggregates. It delivers excellent resolution, with a final aggregate content of <0.3%, and high recovery of >80% from a heterogeneous feed of monoclonal antibody aggregates and monomer. Aggregate content and recovery in the eluate were shown to be functions of the target conductivity measured at the end of collection.
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