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CMC Forum Press Releases
Single-Use Bioreactors with Unparalleled Mixing, Scalability, and Ease of Use
Daniel Giroux
BioProcess International, Vol. 8, No. 7, July–August 2010, p. 130
 



PBS Biotech has emerged into the growing single-use bioprocessing space with an offering truly unlike any other: elegant, powerful, and incredibly easy-to-use bioreactors. A commitment to quality and innovation is evident in every design element of PBS Biotech's Pneumatic Bioreactor System™. The proprietary Air-Wheel™ agitation mechanism powered by gas buoyancy provides unparalleled mixing performance for cell cultivation. The result is rapid liquid mixing, efficient mass transfer, and significantly lower shear stress — all of which remain consistent across the broad range of bioreactor scales offered.

The PBS Biotech platform of fully integrated, modular, single-use bioreactors includes bench-top R&D systems at 3 L and 15 L, pilot-lab systems at 80 L and 500 L, and manufacturing systems at 2,500 L and 5,000 L. The performance and elegance of design in these systems are only rivaled by the simplicity of their controls. The proprietary controller's architecture is logical and well conceived and is combined with an intuitive human interface. Thus, operation is greatly simplified, and the chance for human error is minimized. From across the lab or across an ocean via secure remote access, vital information is clearly visible and easily accessible. Like the Air-Wheel agitation, the control system is also constant across this platform from 3 L up to 5,000 L.





PBS Biotech bioreactors feature solid-state hard drives, redundant sensors, integrated auto-sampling, and easy networking to increase reliability and usability. Each unit is built to order and can be customized to specific requirements for pumps, probes, ports, sensors, and more. Control can be autonomous or tied in to your existing supervisory control system. By nature of the fully integrated and preconfigured modular design, PBS bioreactors arrive ready to use: Just uncrate and connect power and gas lines.

Single-use bioreactors have enabled greater process efficiency and flexibility. To this, PBS Biotech bioreactors now add unparalleled mixing, scalability, and ease of use.

Author Details
Daniel Giroux is director of product development at PBS Biotech, Inc., 4023 Camino Ranchero, Suite I, Camarillo, CA 93012; 1-888-PBS-0022; info@pbsbiotech.com, www.pbsbiotech.com.

 
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Biopharmaceutical Production
Facility Design Strategies for Single-Use Technologies

Please join us for a free webinar addressing strategies for facility design in biopharmaceutical manufacturing:

Wednesday, 29 February 2012
8:00 AM and 1:00 PM EST

Presented by:

Ingrid Long, MSc
Research Engineer
GE Healthcare Life Sciences

Register today!

During the webinar, Ms. Long will discuss the impact of different strategies for facility design, with a focus on the following topics:

* Replacement of traditional equipment with the single-use equivalent
* Biopharmaceutical manufacturing in a single room
* Benefits of facility design with respect to cost, risk, and flexibility

Register today!


Nine Conferences — One Location: Hilton Bayfront (San Diego, CA)
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