Inline Sampling

Product: STA-PURE fluid sampling

Applications: PAT sampling

Features: Gore's sampling system can be directly connected to 25-mm Ingold ports. Previously, such sampling required the use of TC adapters and O rings that can leak or get stuck in vessel ports. The STA-PURE solution uses a high-purity, highly compressible platinum-cured silicone adapter integrated with a single valve device. A single-use silicone sleeve is attached and presterilized with the device. When the valve body is inserted into a vessel port, the sleeve rings are compressed significantly to create redundant seals that will withstand >100-psi fluid pressure.

Contact W.L. Gore & Associates, Inc. www.gore.com/pharmbio

Membrane Chromatography

Product: Mustang Q XT chromatography capsules

Applications: Biopharmaceutical contaminant removal

Features: Mustang Q XT chromatography capsules help process developers reduce purification time, increase throughput, and cut costly buffer consumption. The open-pore structure of Mustang membranes makes these capsules especially useful in high–flow-rate contaminant removal applications and in the capture/removal of large molecules.

Contact Pall Corporation www.pall.com/biopharm_39547.asp

Integrate Disposables

Product: FlexAct system

Applications: Production process design

Features: Designed to help preconfigured single-use solutions meet process requirements, the FlexAct system enables biomanufacturers to use integrated single-use equipment for entire steps in upstream/downstream processes. As a full-fledged workstation, it helps users design efficient and flexible processes with out-of-the-box disposable unit operations. This level of integration and standardization makes it easy for anyone still using stainless steel equipment or individual disposable components to convert to single-use unit operations.

Contact Sartorius Stedim Biotech www.sartorius-stedim.com

CGMP Reagents

Service: Contract manufacturing

Applications: APIs, intermediates, and reagents

Features: BioVectra Inc., a biopharmaceutical CMO with 40 years of experience in product development, released its first round of new bioprocessing reagents that adhere to the company's CGMP quality management system. The company offers both synthetic organic chemistry and biochemistry expertise. Its manufacturing and development technologies include a number of complex synthesis and reaction technologies, high-purity MPEG production, fermentation of an array of biomolecules, and natural product isolation and purification.

Contact BioVectra www.biovectra.com

Increase Consistency

Product: EX-CELL ANTIFOAM solution

Application: Foam control in cell culture bioreactors

Features: EX-CELL ANTIFOAM is a nonanimal-origin solution to enhance foam control in cell culture bioreactors for increasing consistency, efficiency, and stability in biomanufacturing. It is formulated from a 30% simethicone emulsion and validated by a simethicone quantification assay that confirms lot-specific concentration. Through formulation optimization, use of a quantitative assay, and understanding the nonspecific binding of simethicone, a company can report the actual simethicone concentration of the gamma-irradiated finished material.

Contact SAFC (Sigma-Aldrich Group) www.safcglobal.com