Sunday August 20, 2017
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Covering the whole development process for the global biotechnology industry
Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies.
Cell Culture Media
Perfusion Cell Culture
Upstream Contract Services
Upstream Single-Use Technologies
Beginning with harvest of material from a bioreactor, downstream processing removes or reduces contaminants to acceptable levels through several steps that typically include centrifugation, filtration, and/or chromatographic technologies.
Downstream Contract Services
Downstream Single-Use Technologies
Drug products combine active pharmaceutical ingredients with excipients in a final formulation for delivery to patients in liquid or lyophilized (freeze-dried) packaged forms — with the latter requiring reconstitution in the clinical setting.
Manufacturing Contract Services
Many technologies are used to characterize biological products, manufacturing processes, and raw materials. The number of options and applications is growing every day — with quality by design (QbD) giving impetus to this expansion.
Even as it matures, the biopharmaceutical industry is still a highly entrepreneurial one. Partnerships of many kinds — from outsourcing to licensing agreements to consultancies — help companies navigate this increasingly global business environment.
Pre-Clinical and Clinical Trials
Aggregation Analysis of Therapeutic Proteins, Part 3
The Basics of Cleaning and Cleaning Validation
High-Throughput and Quantitative Detection of Residual NS0 and CHO Host Cell Genomic DNA
Quantifying Sterilizing Membrane Retention Performance
Establishing Potency Specifications for Antigen Vaccines
Application of Disposable Pressure Sensors to a Postcentrifugation Filtration Process
How Viscous Fingering Can Spoil Your Separation
Building Process Control into Chromatographic Purification of Viruses, Part 2
Long-Term Stability Study and Topology Analysis of Plasmid DNA By Capillary Gel Electrophoresis
Sterility Assurance with Filtration