Voices of Biotech
Podcast: MilliporeSigma says education vital to creating unbreakable chain for sustainability
MilliporeSigma discusses the importance of people, education, and the benefits of embracing discomfort to bolster sustainability efforts.
August 11, 2016
Sponsored by Repligen
A finalist for the 2012 BPI Technology of the Decade Award, XCell™ ATF systems consistently yield high cell retention, concentration, and viability, enabling efficient and productive perfusion and N – 1 perfusion as well as cell banking and seed-train cell culture operations.
Figure 1: Scalable from laboratory to production: XCell™ ATF systems include the device and controller. XCell™ ATF single-use device (left) are available in two sizes. XCell™ ATF stainless steel device (right) are available in five sizes.
XCell™ ATF devices are now available in single-use format, in addition to stainless steel. The new single-use devices deliver 100% cell retention and laboratory-to-production scalability like their stainless steel counterparts but without the need for autoclave sterilization and lengthy setup times.
Figure 2: Alternating tangential flow (ATF) technology: XCell™ systems use ATF technology created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor.
Features and benefits of XCell™ ATF Systems include
Continuous, provides clarified harvest ready for capture chromatography
Efficient, delivers 100% cell retention to increase productivity
Intensified, generates high cell concentration and viability
Flexible, connects to any bioreactor and can be used in a range of applications
Gentle, reduces cell stress, increases cell viability, and productivity
Easy to use, single-use reduces setup time and documentation
Scalable, adapts from development scale to production scale
Self cleaning, pump action reduces hollow-fiber filter fouling and increases throughput
Figure 3: Continuous processing; high cell density with high viability perfusion at 100E6 cells/mL was achieved using an XCell™ ATF 2 system.
Learn more at www.repligen.com.
Rachel Goodrich is senior director of marketing at Repligen, 41 Seyon Street, Building 1, Suite 100, Waltham, MA 02453; [email protected]; www.repligen.com.
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