Thursday, April 20, 2017 Daily Archives

Optimizing Unit Operations In Biopharmaceutical Manufacturing

There are many critical material-handling challenges regarding flow rates, pressure levels and the prevention of shear in the chromatography, virus filtration and TFF processes that are used in the manufacture of biopharmaceuticals. In order for these unique operations to be implemented successfully while handling fluids that can be sensitive, delicate and expensive, the operator must be aware of their specific operating characteristics and choose a pumping technology that can meet the strict demands for successful operation. While lobe and peristaltic…

Synergizing Transient and Stable Protein Expression for Accelerated Biotherapeutic Development

This webcast features: Krista Steger, PhD, Scientist, MaxCyte Transitioning early stage discovery efforts with later stage development activities is critical for moving biological therapies into the clinic in an efficient and timely manner. MaxCyte’s scalable Flow Electroporation™ Technology allows gram-scale transient expression of antibodies and other proteins in cell types that are relevant to biomanufacturing. At the same time, the high levels of efficiency and viability provided by MaxCyte transfection, can shorten timelines and reduce labor involved in generating clonal cell…

Distek, Inc. Releases Model 2500 Select Bathless Dissolution Tester

Distek, Inc., has released the Model 2500 Select – Bathless Dissolution Tester. The patented bathless technology eliminates the water bath and all associated maintenance while heater jackets raise media temperature from ambient to 37°C in less than 15 minutes. Wireless in-shaft temperature sensors continuously monitor and display the in-vessel temperature for each vessel. A brilliant touch screen and unparalleled command of the instrument with electronic tracking of serialized stirring elements, qualification status and due dates and extensive reporting and method…

Enzo Life Sciences Introduces Innovative Ultra-Sensitive Multiplex IHC Kit

Enzo Life Sciences has released a new immunohistochemistry product, MULTIVIEW® PLUS (mouse-HRP/rabbit-AP) IHC Kit (Brown/Green). This non-biotin nanopolymer detection system contains reagents and materials that detect and localize antigens in formalin-fixed paraffin-embedded tissues. The MULTIVIEW PLUS IHC kit optimizes IHC processes by including the entire workflow, from antigen retrieval to visualization. The MULTIVIEW PLUS system can detect multiple antigens on a single tissue sample, while eliminating the traditional two-step method using biotin/avidin conjugates. The high sensitivity, low background reagents are…

Multi-Gram Scale Antibody Production Using CHO Cell Transient Gene Expression (TGE) via Flow Electroporation™ Technology

Despite advances in transfection methods and culture optimization, many CHO-based TGE systems produce insufficient antibody titers (low mg/L level) for full use within biotherapeutic development pipelines. The high productivity of MaxCyte-driven transient gene expression allows for its use in early phase candidate identification as well as for generating the gram-level antibody quantities needed for later stage pharmacology, stability and manufacturing studies. In this white paper, data are presented demonstrating the reproducibility, scalability and antibody production capabilities of MaxCyte Flow Electroporation™…