Voices of Biotech
Podcast: MilliporeSigma says education vital to creating unbreakable chain for sustainability
MilliporeSigma discusses the importance of people, education, and the benefits of embracing discomfort to bolster sustainability efforts.
January 1, 2008
Validation
Service: Confidence leachables and extractables testing
Applications: Single-use equipment validation
Features: Proprietary analytical techniques have been developed to detect low levels of extractables (including high-performance liquid chromatography, liquid and gas chromatography with mass spectrometry, and Fourier-transform infrared spectroscopy; testing is conducted with each test component in contact with the actual pharmaceutical formulation; other tests offered include bacterial challenge and viability testing, integrity test values analysis, and chemical compatibility testing
Contact Sartorius Stedim Biotech
Fermentation
Product: BioFlo Pro fermentors with ControlLogix controller
Applications: Pilot- and production-scale growth of cells and their by-products (e.g., proteins, biofuels, viral vacines)
Features: With an Allen Bradley ControlLogix controller for advanced system regulation and easy data exchange with auxiliary bioprocessing systems (such as clean-in-place skids); ISA S88-compatible for batch process control; ethernet connection with optional open process control (OPC) server connectivity and a 21 CFR Part 11 SCADA package; modular components enable rapid delivery and customization
Contact New Brunswick Scientific
Protein Production
Product: Trimer Tag expression enhancement
Applications: Trimeric protein production
Features: Patented technology allows pharmaceutical and biotech companies to design and produce any secreted therapeutic proteins in trimeric form by taking advantage of the natural properties of collagen; technology can complement or replace the Fc-Tag technology that has been used to produce dimeric proteins used in blockbuster biotech products and targeting trimeric ligand TNF-α as well as open up new avenues for targeting trimeric ligands
Contact GenHunter
Serum Free Media
Product: ProNS0 protein expression media
Applications: Recombinant protein production in NS0 cells
Features: Consists of two optimized formulas to cover the broadest range of NS0 nutritional needs; maximization of protein production is possible by titration with companion lipid supplement; simplifies product purification, enhances lot-to-lot consistency, and reduces regulatory burdens
Contact Lonza
www.lonzabioscience.com/prod.pronso
Media Optimization
Product: CHO CD EfficientFeed kit
Applications: Fed-batch CHO-based cell culture
Features: Comes with two feed supplements (1 L of each) and a detailed manual that guides users through decisions relating to chemical or physical compatibility; chemically-defined, serum-free CHO media can be used to increase productivity by up to five times that of batch conditions; feeds promote higher protein yields or cell growth kinetics, making maximum protein amounts and more cells for seeding bioreactors available in shorter time
Contact Invitrogen
www.invitrogen.com/bioproduction
Contract Manufacturing
Service: Production alliance
Applications: Manufacturing technology platform includes formulation development for microbial-derived products
Features: Two companies have entered into a production alliance agreement that allows Biomeva GmbH nonexclusive access to Boehringer Ingelheim’s comprehensive manufacturing technology platform; one innovative E. coli project regarding an antibody fragment has been transferred smoothly from Boehringer Ingelheim to Biomeva GmbH; the collaboration provides integrated solutions and accelerates the development and production of biopharmaceuticals, reducing time to market
Contact Biomeva GmbH
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