Voices of Biotech
Podcast: Sustainability equals efficiency, says eXmoor
eXmoor Pharma discusses the steps taken to build a more sustainable facility, the importance of its design, and calls for industry to share advice and initiatives.
September 12, 2023
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Properly scaling from small-scale bioreactors to larger-scale bioreactors for intensified processes is highly dependent on maintaining mixing, oxygenation, nutrient, and process control. To be able to meet these criteria, bioreactor systems need to have a well-characterized design space while considering risks and ways to control hydrodynamic shear. Extensive understanding of the bioreactor design space and the environmental conditions experienced by the cells within the systems’ operating range enables more informed process development and predictable performance across scales.
The Mobius® 3 L Single-Use Bioreactor and the 50-2000 L Mobius® iFlex Bioreactors are designed for efficient cell growth of batch, fed batch, and perfusion upstream processes. The bioreactors are optimized for high volumetric mass transfer (kLa) and power input (W/m3) with low mixing time while balancing shear limits through impeller tip speed and sparger bubble size.
In this study, key parameters of power input, power number, mixing time, tip speed and shear calculations for the Mobius® 3 L Single-Use Bioreactor and the 50- 2000 L Mobius® iFlex Bioreactor impeller designs were characterized. Additionally, kLa and bubble size from all available sparger designs were characterized to help understand bubble shear impact when scaling from 3 L to Mobius® iFlex Bioreactors. Lastly, CO2 stripping efficiency was assessed to understand trends per sparger type during scale-up.
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